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SUMMARY:Blocking of DNA sites of specific recognition by hydrogen peroxide
  molecules in the process of ion beam therary
DTSTART;VALUE=DATE-TIME:20181204T104500Z
DTEND;VALUE=DATE-TIME:20181204T110500Z
DTSTAMP;VALUE=DATE-TIME:20260419T015902Z
UID:indico-contribution-26@indico.bitp.kiev.ua
DESCRIPTION:Speakers: Oleksii Zdorevskyi (Bogolyubov Institute for Theoret
 ical Physics)\nAfter irradiation of cancer cells in the ion beam therapy m
 ethod the concentration of hydrogen peroxide in the cell medium grows sign
 ificantly. But the role of hydrogen peroxide molecules in ion beam therapy
  has not been determined yet. We assume that interaction of peroxide molec
 ules with DNA atomic groups can block the genetic information of the cance
 r cell and lead to its neutralization. To understand the possibility of DN
 A deactivation in the cell\, in the present study the formation of complex
 es of hydrogen peroxide with DNA specific recognition atomic groups is con
 sidered. Using atom-atom potential functions method and quantum-chemical a
 pproach\, based on density functional theory\, the spatial configurations 
 and energy minima for the complexes of peroxide and water molecules with n
 ucleic bases are studied. The obtained data allows us to formulate a new\,
  different from the already known\, mechanism of the ion irradiation actio
 n on living cells\, that can be the key factor in the ion beam therapy tre
 atment.\n\nhttps://indico.bitp.kiev.ua/event/2/contributions/26/
LOCATION:
URL:https://indico.bitp.kiev.ua/event/2/contributions/26/
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